African Sausage Tree is a widely used herbal treatment in Africa, being used in the treatment of a great many complaints. The fruits are most commonly used, though all parts of the plant have similar properties The diversity of complaints against which the plant is used includes digestive problems, fainting, anaemia, sickle-cell anaemia, epilepsy, respiratory ailments, hepatic and cardiac disorders and nutritional illnesses such as kwashiorkor, rickets, wasting and weakness. Modern research supports the traditional uses and the plant has become an ingredient of commercially produced applications for treating skin problems.
Of the phytochemicals elucidated in extracts of the plant, the compound groups to which activity is most frequently attributed are Naphthoquinones and Iridoids. Extracts of the bark, wood, roots and fruits possess anti-bacterial and anti-fungal properties. These extracts exhibit significant inhibitory effects in vitro against common Gram-negative and Gram-positive bacteria and the yeast Candida albicans. Of the Naphthoquinones isolated in fruit and root extracts, Kigelinone has shown notable anti-microbial activity. Iridoids and Dihydroisocoumarins in extracts of the bark, fruits and roots may enhance the anti-microbial activity of Naphthoquinones. Other active anti-microbial compounds present in the bark and are the Phenylpropanoids Caffeic Acid, p-Coumaric Acid and Ferulic Acid.
The plant is renowned for damaged cell removal properties and laboratory screening has confirmed in-vitro this activity. Fruit extracts exhibited significant effects against induced damaged cells. Fruit and bark extracts have shown moderate efficacy against damaged skin cell lines. The Naphthoquinones, Lapachol and Isopinnatal, in some extracts of bark, wood, fruits and roots, exhibit anti-neoplastic activity against damaged skin cell lines. Sterols and Iridoids are ubiquitous in the plant and may be a factor in the activity against damaged skin cells. The reported cytotoxicity of the root in the brine shrimp assay was attributed to the presence of γ-Sitosterol. The fruits have demonstrated anti-inflammatory actions in vivo. Cinnamic Acid derivatives are thought to be responsible for anti-convulsant properties for which the plant is used to prevent epileptic fits.
The leaves and fruits contain Flavonoids. A high concentration of Flavonoids may be responsible for anti-diarrhoeal properties, increased by anti-microbial constituents. In contrast to the use of the plant as a laxative, preliminary studies have shown a preventive effect of leaf extracts against diarrhoea. The plant is used particularly to remedy a wide range of skin problems. Powders and infusions of the bark, leaves, stems, twigs or fruits are all used to clean and dress flesh wounds and open sores. Many dressings, topical treatments and infusions containing this species are also used for their analgesic and anti-inflammatory properties.
The bark, stems, twigs, leaves and fruits are infused and taken orally or applied locally, to relieve rheumatism, sprains, haematoma and bruising. Snake bite antidotes are made with an infusion of the fruits, stems, leaves, twigs or bark, taken orally or rubbed onto the bite. Infectious diseases, including leprosy, impetigo and worm infestations in the blood, are all treated with this plant. Dermal complaints and infections, such as whitlows, cysts, acne and boils, are treated with traditional medicines containing the fruits, and less frequently, the bark. Sore eyes are treated with drops made from flower sap mixed with water.
The fruits are pendulous, up to 45cm long by 15cm diameter and resemble a 'German' sausage. They are the most commonly used part of the tree, being widely viewed as a fetish with magical properties to enhance their medicinal virtues. The fruits are not edible, even when fully ripe, and are said to be aphrodisiac, intoxicant, purgative and toxic.
In particular, the fruit is used to increase breast size and function. It is given in decoction and also massaged into the breasts of young girls before puberty to promote development, a practice said to be proven by recorded measurements. Infusions and decoctions are applied as a wash or rub to promote weight gain in infants. The fruit is used to increase milk flow. The fruit and roots, along with the 'male' tassel of the plantain inflorescence, are boiled together to make a women's nostrum.